5 Frequentely Asked Questions about a Kombiglyze XR Lawsuit

2/19/2023

Contact Kombiglyze XR lawyer Timothy L. Miles today to see if you are eligible for a Kombiglyze XR lawsuit

Kombiglyze XR is a combination of metformin (a biguanide) and saxagliptin (a DPP4 inhibitor). Kombiglyze XR works by lowering the amount of sugar made by your liver, decreasing the amount of sugar absorbed by your intestine, increasing the amount of insulin your body makes, and helps your body respond better to insulin.

However, research shows that type 2 diabetes drug Kombiglyze XR (saxagliptin and metformin) may cause heart failure or other cardiovascular injuries in some patients. According to the Centers for Disease Control and Prevention (CDC), 30 million Americans have diabetes and 84 million have pre-diabetes. Metformin—one of the drugs found in combination drug Kombiglyze—is among the top 10 most popular prescription drugs taken by Americans. Analysts also predict that Onglyza (saxagliptin), Kombiglyze’s sister drug, could reach $1.8 billion in sales in 2018.

In 2015, roughly 386,000 people were prescribed Onglyza or Kombiglyze XR, the U.S. Food and Drug Administration (FDA) reported. Given that so many people take these drugs, any side effects they may cause that are severe enough to hospitalize patients should be treated with concern. Dozens of patients are filing lawsuits against Kombiglyze’s manufacturer AstraZeneca and its previous partner Bristol-Myers Squibb alleging that the companies failed to adequately test the drugs’ safety prior to selling it, which ultimately caused their cardiovascular injuries.

If you or a loved one took Kombiglyze XR as directed and suffered from Kombiglyze XR side effects including heart failure or other cardiovascular injuries—such as congestive heart failure or myocardial infarction, after starting Kombiglyze XR therapy, contact Kombiglyze XR lawyer Timothy L. Miles today to see if you are eligible for a Kombiglyze XR lawsuit and possibly entitled to substantial compensation.

Read on for answers to five frequently asked questions about a Kombiglyze XR lawsuit.

What Are the Kombiglyze XR Side Effects?

The following are some of the common Kombiglyze XR side effects:

Diarrhea
Nausea and vomiting
Headache
Upper respiratory tract infection (a viral infection that affects the nose, throat, and airways)
Bladder infection
Runny or stuffy nose and sore throat

Additionally, dozens of lawsuits allege other Kombiglyze XR side effects including serious cardiovascular injury.

What Is the Problem with Kombiglyze XR?

Research shows Kombiglyze XR and other similar drugs may put patients at risk of heart complications. Dozens of patients are filing lawsuits against Kombiglyze’s manufacturer AstraZeneca and its previous partner Bristol-Myers Squibb alleging that the companies failed to adequately test the drugs’ safety prior to selling it, which ultimately caused their cardiovascular injuries.

Does Kombiglyze XR Put Patients at Risk of Heart Failure?

A clinical trial funded by AstraZeneca and Bristol-Myers Squibb was one of the first studies to report cardiovascular health risks associated with these drugs.

Saxagliptin Assessment of Vascular Outcomes Recorded in Patients with Diabetes Mellitus, or the SAVOR trial, found that patients with a history of heart problems who took Onglyza or Kombiglyze XR had a 27% greater chance of being hospitalized for heart failure than patients who took a placebo. Patients with chronic kidney disease and / or previous heart failure were more likely to be hospitalized.

When an FDA panel reviewed the results from the SAVOR study, 14 out of 15 panelists voted to require a safety warning on all Onglyza and Kombiglyze XR bottles that the drugs could result in cardiovascular injury.

What Do the Kombiglyze XR Lawsuits Allege?

Kombiglyze XR lawsuits allege that AstraZeneca and Bristol-Myers Squibb failed to:

Warn the FDA, the medical community, and the general public of the cardiovascular risks associated with these drugs.
Conduct adequate pre-clinical and clinical testing to determine if the drugs caused increased risks of cardiovascular injuries.
Design the drugs so as to minimize certain adverse effects.
Conduct adequate post-market monitoring of saxagliptin’s adverse events

If I Meet the Requirements for a Kombiglyze XR lawsuit, What Can I Get?

If you meet the requirements for a Kombiglyze XR lawsuit and are successful you can recover money for some of the following damages:
   • Past and future medical bills (including medication, hospital stays, and in-home care)
     • Pain and suffering
     • Lost wages
     • Loss of earning capacity
     • Funeral expenses (in the event of a loved one’s death)

Broadly speaking, a plaintiff who is eligible for a Kombiglyze XR lawsuit could be entitled to compensation for any past and future costs associated with their diagnosis if they meet the requirements for a Kombiglyze XR lawsuit and are successful.

Conclusion

If you or a loved one took Kombiglyze XR as directed and suffered from Kombiglyze XR Side Effects, specifically: heart failure or other cardiovascular injuries—such as congestive heart failure or myocardial infarction, after starting Kombiglyze XR therapy, contact Kombiglyze XR lawyer Timothy L. Miles today to see if you are eligible for a Kombiglyze XR lawsuit and possibly entitled to substantial compensation.

Timothy L. Miles, Esq.

Timothy L. Miles is a nationally recognized shareholder rights attorney raised in Nashville, Tennessee. Mr. Miles was recently selected by Martindale-Hubbell® and ALM as a 2022 Top Ranked Lawyer, 2022 Top Rated Litigator. and a 2022 Elite Lawyer of the South. Mr. Miles also maintains the AV Preeminent Rating by Martindale-Hubbell®, their highest rating for both legal ability and ethics. Mr. Miles is a member of the prestigious Top 100 Civil Plaintiff Trial Lawyers: The National Trial Lawyers Association, a superb rated attorney by Avvo, a recipient of the Lifetime Achievement Award by Premier Lawyers of America (2019) and recognized as a Distinguished Lawyer, Recognizing Excellence in Securities Law, by Lawyers of Distinction (2019). Mr. Miles has published over sixty articles on various issues of the law, including class actions, whistleblower cases, products liability, and more. Please visit our website.

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